Valle de Guadalupe, just 90 miles south of San Diego in northern Baja, is a rustic wine destination that's already being called the Napa of Mexico. The valley is located about 14 miles from the city of Ensenada. The easiest way to get to Valle de Guadalupe is to cross the Mexico border by car in Tijuana or Tecate. From San Diego, you can cross the Mexico border at San Ysidro in Tijuana and follow route 1. The distance between Tijuana and Valle de Guadalupe is 61 km.